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KMID : 0043319930160020168
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Archives of Pharmacal Research
1993 Volume.16 No. 2 p.168 ~ p.174
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Synthesis and Pharmacological Studies of Some Pyrone and Benzodifuran Derivatives
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Husgnat Orcgudee-H.
El-Diwani Hoda-I.
Sherifa-M.A.Bakr
Sawsan-S. Mahmoud
Somaya-A. Nada
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Abstract
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The michael adducts 2a, b were obtained from the reaction of the phenylacelyl derivative 1 with benzadehyde and p-anisaldehyde and p-anisaldehyde respectively. 2a and 2b were subjected to react with cyanoethanoic acid hydrazide, malononitrile, cyanothioacetamide, cyanoacetamide and 1, 1, 3-tricyano-2-amino propene to yield 4a-h and 5a, b respecitively. Hydrogen peroxide oxidation of 2a, b gave the aurone derivative 6a, b. The pyone derivatives 8a, b were obtained from 2a, b by addition of chioroacetyl chioride followed by dehydrochlorination.
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KEYWORD
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Chalcones, Michael aducts, Antiinflammatroy agents, Anticoagulants
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